Epitome of the Pharmacopeia of the United States and the National Formulary Part 26

_Elixir Terpini Hydratis et Codeinae (Elix. Terpin. Hyd. et Codein.), Elixir of Terpin Hydrate and Codeine, N.F._--Codeine (0.2%) and elixir of terpin hydrate. Absolute alcohol content about 42 per cent.

DOSAGE: 4 Cc. or 1 fluidrachm (N.F.). This dose contains about 0.008 Gm. or 1/8 grain of codeine, and about 0.07 Gm. or 1-1/6 grains of terpin hydrate.

=*Codeinae Phosphas (Codein. Phos.), Codeine Phosphate, U.S.P.=

White, odorless, efflorescent powder. Freely soluble in water (1:2.3) and slightly soluble in alcohol (1:325).

ACTION AND USES: Same as those of codeine; preferred for hypodermic use.

DOSAGE: 0.03 Gm. or 1/2 grain (U.S.P.).

=*Codeinae Sulphas (Codein. Sulph.), Codeine Sulphate, U.S.P.=

White, odorless, efflorescent crystals or powder. Soluble in water (1:30) and very slightly soluble in alcohol (1:1280).

ACTION AND USES: Same as those of codeine. Preferred for hypodermic injections.

DOSAGE: 0.03 Gm. or 1/2 grain (U.S.P.).

_Syrupus Codeinae (Syr. Codein.), Syrup of Codeine, N.F._--Codeine sulphate (0.2%) and syrup.

USES: Superfluous.

DOSAGE: 4 Cc. or 1 fluidrachm (N.F.)

=Coffea Tosta (Coff. Tost.), Coffee, N.F.= (Roasted Coffee).

ACTION AND USES: Beverage and flavor.

_Fluidextractum Coffeae (Fldext. Coff.), Fluidextract of Coffee, N.F._ (Fluidextractum Coffeae Tostae, N.F. III).--Coffee (100%). Absolute alcohol content about 20 per cent.

DOSAGE: 2 Cc. or 30 minims (N.F.).

=Colchici Cormus (Colch. Corm.), Colchic.u.m Corm, U.S.P.= (Colchic.u.m Root).--Yields not less than 0.35 per cent. of colchicine.

ACTION AND USES: Said to be antineuralgic and a.n.a.lgesic; frequently used in the treatment of acute gouty attacks and to some extent to ward off such attacks. Full doses produce watery stools and abdominal pains.

DOSAGE: 0.25 Gm. or 4 grains (U.S.P.), in pills; or preferably as the tincture.

_Extractum Colchici Cormi (Ext. Colch. Corm.), Extract of Colchic.u.m Corm, U.S.P._ (Powdered Extract of Colchic.u.m Corm).--One Gm. extract represents 4 Gm. colchic.u.m corm and yields about 1.4 per cent. of colchicine.

DOSAGE: 0.06 Gm. or 1 grain (U.S.P.).

_Fluidextractum Colchici Cormi (Fldext. Colch. Corm.), Fluidextract of Colchic.u.m Corm, N.F._--Colchic.u.m corm (100%), yielding about 0.35 per cent. of colchicine. Absolute alcohol content about 55 per cent.

DOSAGE: 0.2 Cc. or 3 minims (N.F.).

_Vinum Colchici Cormi (Vin. Colchic. Corm.), Wine of Colchic.u.m Corm, N.F._--Colchic.u.m corm (40%) yielding about 0.14 per cent. of colchicine, in alcohol and sherry wine. Absolute alcohol content about 30 per cent.

DOSAGE: 0.6 Cc. or 10 minims (N.F.).

=*Colchici s.e.m.e.n (Colch. Sem.), Colchic.u.m Seed, U.S.P.= (Colchici s.e.m.e.n P.I.).--Yields not less than 0.45 per cent. of colchicine.

ACTION AND USES: Same as those of colchic.u.m corm.

DOSAGE: 0.2 Gm. or 3 grains (U.S.P.).

_Fluidextractum Colchici Seminis (Fldext. Colch. Sem.), Fluidextract of Colchic.u.m Seed, U.S.P._--Colchic.u.m seed (100%), yielding about 0.4 per cent. of colchicine. Absolute alcohol content about 55 per cent.

DOSAGE: 0.2 Cc. or 3 minims (U.S.P.).

_*Tinctura Colchici Seminis (Tr. Colch. Sem.), Tincture of Colchic.u.m Seed, U.S.P._ (Colchici Tinctura P.I.).--Colchic.u.m seed (10%), yielding about 0.04 per cent. of colchicine; in alcohol and water. Absolute alcohol content about 56 per cent.

DOSAGE: 2 Cc. or 30 minims (U.S.P.).

_Vinum Colchici Seminis (Vin. Colch. Sem.), Wine of Colchic.u.m Seed, N.F._--Fluidextract of colchic.u.m seed (10%), yielding about 0.04 per cent. of colchicine; in alcohol and sherry wine. Absolute alcohol content about 35 per cent.

DOSAGE: 2 Cc. or 30 minims (N.F.).

=Colchicina (Colchicina), Colchicine, U.S.P.=--An alkaloid obtained from colchic.u.m.

Pale yellow, odorless scales or powder. Freely soluble in alcohol, soluble in water (1:22) and slightly soluble in ether (1:220).

ACTION AND USES: Same as those of colchic.u.m corm.

DOSAGE: 0.5 mg. or 1/120 grain.

=COLLODIA, COLLODIONS.=--Collodions are solutions of pyroxylin or soluble gun cotton with medicinal agents, for external application. For the official collodions see under the names of the princ.i.p.al ingredients. In particular, for Collodium, see under =Pyroxylin=; for Collodium Flexible, under =Oleum Ricini=; and for Collodium Styptic.u.m, under =Acidum Tannic.u.m=.

=*Colocynthis (Colocyn.), Colocynth, U.S.P.= (Colocynth Pulp, Bitter Apple, Colocynth Apple).

ACTION AND USES: A powerful irritant hydragogue cathartic. Because of its drastic nature it is rarely used alone. The various compound pills listed below are needlessly complex and therefore irrational. Because of their irritant character, they are especially unsuited for continued use.

DOSAGE: 0.06 Gm. or 1 grain.

_*Extractum Colocynthidis (Ext. Colocynth.), Extract of Colocynth, U.S.P._ (Powdered Extract of Colocynth).--One Gm. of extract represents 4 Gm. of colocynth.

DOSAGE: 0.015 Gm. or 1/4 grain (U.S.P.).

_*Extractum Colocynthidis Compositum (Ext. Colocynth. Co.), Compound Extract of Colocynth, U.S.P._ (Powdered Compound Extract of Colocynth).--Extract of colocynth (16%), aloes (50%), resin of scammony (14%), cardamom seed and soap.